723 Common and different roles of dermokine in skin diseases based on mouse genetic background
نویسندگان
چکیده
Dermokine (DMKN) is a secreted glycoprotein expressed predominantly in the upper epidermis, particularly granular layers, whose expression pattern resembles terminal differentiation molecules. It comprises three splice variants mice and five humans. Our recent investigation generating all isoforms of DMKN deficiency C57BL/6 [DMKN-KO(B6)] demonstrated ichthyosiform skin with transepidermal water imbalance, Th17-prone immune response, average molecular permeability early neonatal stage, resulting lethal under low humidity. In adult DMKN-KO(B6), imiquimod- IL-23-induced psoriasis models were exacerbated, while atopic model induced by ovalbumin transdermal sensitization was comparable to wild-type. However, influence may also depend on genetic background mice. Therefore, we newly established DMKN-KO BALB/c [DMKN-KO(BALB/c)]. The DMKN-KO(BALB/c) reproduced period but somewhat milder better prognosis than DMKN-KO(B6). Unlike experimental findings B6 background, transcutaneous elicitation exhibited significantly higher serum titer antigen-specific IgE DMKN-KO(B6) wild-type(BALB/c). Consistent this, thickness inflammatory cell infiltration exacerbated DMKN(BALB/c). phenotype recombinant as aggravated disease-related cytokines lesional correlated severity each model. Exacerbation IL-23 subcutaneous injection suggests that acts immunity independently its role maintaining homeostasis keratinization barrier function. have unique regulatory roles pathogenesis ichthyosis, dermatitis, psoriasis, depending immunogenetic background.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.732